Thanks a lot for your interesting questions.
The genetics aspect in the current version of Sacrifices is rather poor actually. We had some attempts to make this interesting but eventually deemed them not worth it and kept the game in a simpler form.
Hence the more efficient way, right now, to perform genetics selection is by selective sacrificing.
Moreover, gender change in the game will only affect a follower's ability to get pregnant. No long-term difference between male and female followers.